
Chelation
Nation

Each metal poisons differently
Introducing... Gadolinium (Gd)
Besides the use of GBCA's (gadolinium-based contrast agents) during MRA Angiograms or MRI's with CONTRAST of soft tissues in the body, the only other "known" way to become exposed to gadolinium is in the computer keyboard manufacturing industry and in the manufacture of smart phone speakers and microphones.
Gadolinium must be chelated before injection. In the body, it then becomes un-glued...
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99% of Gadolinium exposures are via MRI injections and MRA (angiogram) injections. Workplace exposures and poisoning does occur (see San Fransisco Bay silicon valley keyboard manufacture)
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Babies and infants are also exposed to MRI gadolinium.
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Gadolinium injection can take many years/decades to leave the body.
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Gadolinium left in the body would require 60 years to leave naturally.
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The top three most popular Gadolinium injection products are also the most unstable and poisonous of the 7 total on the market, as of 2010
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Gadolinium symptoms can appear 6+ months after injection, so tracing the problem to the "smoking gun" source is very difficult.
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Patients with kidney disease are likely to have immediate poisoning by Gd, while patients with perfect kidneys will get chronic (undiagnosed) poisoning from Gadolinium.
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The MRI you had to investigate your symptoms may, itself, be actually promoting or even DIRECTLY CAUSING the worsening of your disease.
Gadolinium was first smelted and "discovered" in the year 1880. Gadolinium was first used in industry in the 1980's. Gadolinium was first used in medicine in the year 1988. Gadolinium has been known to be a potent medical poison since the year 1997. Anti-gadolinium lawsuits first began in the year 2008. Today, Gadolinium is given to tens on millions of patients each year in the US alone. Gadolinium now has expanded FDA black box warnings as of 2010.
"TRANS-METALLATION" is a big word that means "swapping one metal out for another."
-Gadolinium can only be "safely" injected into a body if it is "caged/bound/chelated" inside a safe CHELATE molecule that has been created for the purpose. Inside this "cage" or "clamshell" it is still magnetic (so it is useful for magnetic resonance imaging-MRI), and yet it is not allowed out of the cage to "react" with the proteins etc of the body, as Gd is poisonous.
-HOWEVER, other heavy metals (mercury, zinc, phosphorus) inside a body ALSO want to get inside the cage, and are known to OUTCOMPETE the Gd or "UNLOCK the weak cage locks," jump into the cage themselves, and kick the gadolinium out.
-For example, Zinc denture cream is known to release Gadolinium from it's cage. Mercury, Lead and others do something similar. This unleashed Gadolinium is then left behind to creates chronic disease states in the body.
"EXTRA-VASATION" is a big word that means the radiology tech's needle missed (or poked all the way through to the other outside of) the vein and what was supposed to go into your bloodstream (and exit via kidneys) got left behind in a muscle or nearby tissue where it takes inifitely longer to get removed from the body and has longer time to react with nearby tissues. Extravasated Gadolinium has more time to "unzip" from it's binder and be left behind, in the body, instead of exiting through the kidneys as it is "supposed to."
Symptoms associated with ANY level of Gadolinium in the body:
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wherever the Gadolinium goes and gets trapped, calcification and phosphate accumulation build up in random tissues throughout the body like buckshot. (The body lays down "bone" to "pearlize" the Gadolinium; thus, body tissues harden, stiffen, and become "paralyzed from the outside-in" as if the dermal layers are now made of tree bark, taught dry leather, or "tin man" armor.)
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Skin changes akin to fibrosis of the skin and muscles, especially on limbs, eye and vision changes, optic floaters, large lumps on limbs near joints, brain fog,
Current tips on testing for Gadolinium in the body: 2023
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Fecal test: before and after HOPO is best, next best is OSR, next best is large dose oral DMSA, next best EDTA IV +lg dose oral DMSA.
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Urine challenge with IV EDTA will see only some of the Gadolinium.
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Invasive biopsy of suspicious tissue are the only ways to reliably find gadolinium. Mayo clinic does blood serum testing for it.
Tips on Chelation of Gadolinium from the body
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EDTA iv's in a body with with lots of silver fillings in your mouth may cause mobilization of mercury, so it is necessary to read up on that if you have them.
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I.V. EDTA is known to chelate Gadolinium very slowly, while oral EDTA does not.
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Suppository EDTA should work, but we don't know how much. DMSA does not remove gadolinium.
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Experimentation with the use of DTPA shows efficacy but weak binding, so many flares, resurfacing symptoms and .
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Chelation of Gadolinium is fairly new in online patient experience, circa roughly 2009.
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Underground patient experience with HOPO is showing promise as of 2023.
In the NEWS
2024: https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1376587/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE&fbclid=IwZXh0bgNhZW0CMTEAAR1jw8kqhD4acoZ3kydgMxBFzy85nfkWvoWhsJJIlpvJqsFtqlLf8NydU2M_aem_iMyoDhzFHFBikjPtY0H6oQ#B106
2013
GE pays 5 Million to victim of Gadolinium
https://www.robertkreisman.com/injury-lawyer/5-million-verdict-in-first-gadolinium-injury-trial/
GE in court for Omniscan Dye, unsafe
http://www.propublica.org/article/burn-the-data-did-a-company-try-to-hide-risks-of-ges-mri-dye
Some Examples of Peer Reviewed Research
(files are grouped by year, not by publishing date)
2011
Recent hot topics in contrast media
http://www.springerlink.com/content/qv4r61613t10n22x/fulltext.pdf
2011
Toxic effects of mercury, lead and gadolinium on vascular reactivity
http://www.scielo.br/pdf/bjmbr/v44n9/1088.pdf
2010
Gadolinium-based Magnetic Resonance Contrast Agents and Nephrogenic Systemic Fibrosis
http://www.touchnephrology.com/articles/gadolinium-based-magnetic-resonance-contrast-agents-and-nephrogenic-systemic-fibrosis?page=0,4
2010
Nephrogenic systemic fibrosis presenting as myopathy: A case report with histopathologic correlation
http://www.nmd-journal.com/article/S0960-8966(10)00166-5/abstract
2010
Novel Sorbents for Removal of Gadolinium-Based Contrast Agents in Sorbent Dialysis and Hemoperfusion: Preventive
Approaches to Nephrogenic Systemic Fibrosis (NSF)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862574/pdf/nihms118116.pdf
2010
The Biodistribution of [153Gd]Gd-Labeled Magnetic Resonance Contrast Agents in a Transgenic Mouse Model of Renal Failure Differs Greatly from Control Mice
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180881/?tool=pubmed
2010
Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity.
http://www.ncbi.nlm.nih.gov/pubmed/20398695
2009
Gadolinium Containing Containing Contrast Agent Promotes Multiple Myeloma Cell Growth: Implication for Clinical Use of MRI in Myeloma
http://myeloma.org/pdfs/ASH2009_Fulciniti_1809.pdf
2010
Zinc Transmetallation and Gadolinium Retention after MR Imaging: Case Report
http://radiology.rsna.org/content/257/3/670.full
2009
http://radiology.rsna.org/content/253/2/390.full.pdf
2009
Persistence of Gadolinium Contrast Enhancement in CSF: A Possible Harbinger of Gadolinium Neurotoxicity?
http://www.ajnr.org/content/30/1/e1.full.pdf
2009
Long-term retention of gadolinium in the skin of rodents following the administration of gadolinium-based contrast agents
http://www.springerlink.com/content/30g331p7p8438w21/fulltext.pdf
2009
Gadolinium-Based Contrast Agents & Nephrogenic Systemic Fibrosis: FDA Briefing Document
http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee/UCM190850.pdf
2008
Possibly enhanced Gd excretion in dialysate, but no major clinical benefit of 3–5 months of treatment with sodium thiosulfate in late stages of nephrogenic systemic fibrosis
http://ndt.oxfordjournals.org/content/23/10/3280.long
2008
Nephrogenic Systemic Fibrosis with Multiple Calcification and Osseous Metaplasia
http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-0518&html=1
2007
Case-control study of gadodiamide-related nephrogenic systemic fibrosis
http://ndt.oxfordjournals.org/content/22/11/3174.full.pdf+html
2007
http://www.diagnosticimaging.com/conference-reports/ismrm2007/article/113619/1184977
2007
Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis.
http://www.ncbi.nlm.nih.gov/pubmed/18067485
2007
Nephrogenic Fibrosing Dermopathy Associated with Exposure to Gadolinium-Containing Contrast Agents --- St. Louis, Missouri, 2002--2006
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5607a1.htm
2007
New Insights into Nephrogenic Systemic Fibrosis, Sundararaman Swaminathan and Sudhir V. Shah
http://jasn.asnjournals.org/content/18/10/2636.full
2007
Nephrogenic Systemic Fibrosis: A Mysterious Disease in Patients with Renal Failure—Role of Gadolinium-Based
Contrast Media in Causation and the Beneficial Effect of Intravenous Sodium Thiosulfate
http://cjasn.asnjournals.org/content/2/2/258.full.pdf
2007
Nephrogenic Systemic Fibrosis Mimicking Inflammatory Breast Carcinoma
http://www.archivesofpathology.org/doi/pdf/10.1043%2F1543-2165(2007)131%5B145%3ANSFMIB%5D2.0.CO%3B2
2007
What nephrologists need to know about gadolinium
http://www.nature.com/nrneph/journal/v3/n12/full/ncpneph0660.html
2006
Methods of diagnosing and alleviating gadolinium toxicity Patent Application
http://www.freshpatents.com/Methods-of-diagnosing-and-alleviating-gadolinium-toxicity-dt20080612ptan20080138440.php
2003
Pseudohypocalcemia with MR Imaging Contrast Agents: A Cautionary Tale
http://radiology.rsna.org/content/227/3/627.full
2002
Are Gadolinium-based Contrast Media Really Safer than Iodinated Media for Digital Subtraction Angiography in Patients with Azotemia?
http://radiology.rsna.org/content/223/2/311.full#sec-4
1995
Neurotoxic Effects of Gadopentetate Dimeglumine: Behavioral Disturbance and Morphology after Intracerebroventricular
Injection in Rats
http://www.ajnr.org/content/17/2/365.full.pdf
1965
SOFT-TISSUE CALCIFICATION INDUCED BY RARE EARTH METALS AND ITS PREVENTION BY SODIUM PYROPHOSPHATE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510795/pdf/bripharmchem00023-0007.pdf